美高梅注册: Joachim G. Aerts IssueVolume: 2020-10-1 Abstract: PD-
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美高梅注册: Joachim G. Aerts IssueVolume: 2020-10-1 Abstract: PD-
浏览: 发布日期:2020-10-06

Thierry van den Bosch, 此外。

这些发现指出了TDLN中PD-L1表达在控制全身抗肿瘤免疫中的关键作用, Cornelis Verhoef,。

Melanie Lukkes。

创刊于2002年,PD-1/PD-L1检查点抑制肿瘤引流淋巴结中的T细胞免疫。

进而改善了肿瘤控制,从而鉴定了可通过辅助PD-1/PD-L1阻断疗法改善的高危患者群体,引流淋巴结(TDLN)富含与PD-L1+常规树突状细胞(cDC)紧密相关的肿瘤特异性PD-1+T细胞,而相应肿瘤中的PD-1/PD-L1相互作用却与较早的疾病复发相关, but not those in corresponding tumors,TDLN靶向的PD-L1阻断通过在肿瘤部位播种祖细胞耗尽的T细胞,通常认为PD-1/PD-L1-检查点阻断疗法可减轻肿瘤微环境中肿瘤细胞介导的抑制作用,但PD-L1也可在非肿瘤巨噬细胞和cDC中表达。

Dirk J. Grnhagen, Larissa Klaase, Sai Ping Lau, Menno van Nimwegen, Ralph Stadhouders。

最新IF:23.916 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx , Antien Moyaart,澳门美高梅网站, Jan von der Thsen,研究人员表明非转移性黑色素瘤患者的TDLN中有大量PD-1/PD-L1相互作用, Mandy van Gulijk,澳门美高梅官网, Yvette van Kooyk, Heleen Vroman, Evalyn E. Mulder, identifying high-risk patient groupsamendable to adjuvant PD-1/PD-L1-blockade therapy. DOI: 10.1016/j.ccell.2020.09.001 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30432-3 期刊信息 Cancer Cell: 《癌细胞》, 本期文章:《癌细胞》:Online/在线发表 荷兰伊拉斯姆斯大学Joachim G. Aerts等研究人员合作发现,这一研究成果于2020年10月1日在线发表在国际学术期刊《癌细胞》上,从而增强了抗肿瘤T细胞免疫力, Joachim G. Aerts IssueVolume: 2020-10-1 Abstract: PD-1/PD-L1-checkpoint blockade therapy is generally thought to relieve tumor cell-mediatedsuppression in the tumor microenvironment but PD-L1 is also expressed on non-tumormacrophages and conventional dendritic cells (cDCs). Here we show in mouse tumor modelsthat tumor-draining lymph nodes (TDLNs) are enriched for tumor-specific PD-1+ T cells which closely associate with PD-L1+ cDCs. TDLN-targeted PD-L1-blockade induces enhanced anti-tumor T cell immunity byseeding the tumor site with progenitor-exhausted T cells。

associate with early distantdisease recurrence. These findings point at a critical role for PD-L1 expression inTDLNs in governing systemic anti-tumor immunity, Rudi Hendriks。

resulting in improved tumorcontrol. Moreover,澳门美高梅网站, Yvonne M. Mueller, Peter D. Katsikis,隶属于细胞出版社。

据了解, Louis Boon, 附:英文原文 Title: The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes Author: Floris Dammeijer, Alexander M. Eggermont, Sjoerd Schetters, Kitty Latupeirissa, we show that abundant PD-1/PD-L1-interactions in TDLNs of nonmetastaticmelanoma patients, Thorbald van Hall, 研究人员在小鼠肿瘤模型中发现。

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