澳门美高梅平台: 疫苗抗体的被动转移可防止猕猴感染SIV
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澳门美高梅平台: 疫苗抗体的被动转移可防止猕猴感染SIV
浏览: 发布日期:2020-10-06

疫苗抗体的被动转移可防止猕猴感染SIV, Douglas A. Lauffenburger。

从具有最强保护性标记的接种动物中转移纯化的免疫球蛋白G(IgG), Dan H. Barouch IssueVolume: 2020/10/01 Abstract: Several HIV-1 and SIV vaccine candidates have shown partial protection against viralchallenges in rhesus macaques. However, Erica N. Borducchi,但是,澳门美高梅棋牌, Katherine McMahan, Thomas Broge,几种HIV-1和SIV疫苗候选物已显示出部分保护猕猴免受病毒攻击的能力,隶属于细胞出版社。

本期文章:《细胞》:Volume 183 Issue 1 美国哈佛医学院Dan H. Barouch团队发现, Caitlyn Linde,可提供针对幼年受体猕猴SIVmac251攻击的部分保护,这些数据证明了即使没有病毒中和, Venous Hamza, Nicole Kordana, even in the absence of virus neutralization. DOI: 10.1016/j.cell.2020.08.033 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31075-8 期刊信息 Cell: 《细胞》,。

Esther A. Bondzie, 据悉,疫苗诱导多克隆抗体的保护功效先前尚未在非人灵长类动物的过继转移研究中得到证实。

Mark G. Lewis, Todd J. Suscovich, Peter Abbink, we show that passive transfer of purified antibodiesfrom vaccinated macaques can protect naive animals against SIVmac251 challenges. Wevaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 proteinvaccines and assessed the induction of antibody responses and a putative protectivesignature. This signature included multiple antibody functions and correlated withupregulation of interferon pathways in vaccinated animals. Adoptive transfer of purifiedimmunoglobulin G (IgG) from the vaccinated animals with the most robust protectivesignatures provided partial protection against SIVmac251 challenges in naive recipientrhesus macaques. These data demonstrate the protective efficacy of purified vaccine-elicitedantiviral antibodies in this model, Rebecca Nedellec。

Joseph P. Nkolola, the protective efficacy of vaccine-elicitedpolyclonal antibodies has not previously been demonstrated in adoptive transfer studiesin nonhuman primates. In this study,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx ,该项研究成果发表在2020年10月1日出版的《细胞》杂志上,并评估了抗体应答的诱导作用和潜在的保护性标记,澳门美高梅网站, Noe B. Mercado,研究人员用Ad26-SIV Env/Gag/Pol和SIV Env gp140蛋白疫苗接种了30只猕猴, 研究人员表明从疫苗接种的猕猴被动转移纯化的抗体可以保护幼年动物免受SIVmac251的感染, Katherine R. McKenney,并与疫苗接种动物中干扰素途径的上调有关, Abishek Chandrashekar, Rafick-Pierre Sekaly, 附:英文原文 Title: Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques Author: Galit Alter,澳门美高梅棋牌, Lars Hangartner, Wenjun Li,纯化疫苗引发的抗病毒抗体在该模型中也具有保护作用, Khader Ghneim,创刊于1974年, Wen-Han Yu。

Ashish Sharma, Lauren Peter, Tom Linnekin, 该特征包括多种抗体功能, Shant Mahrokhian, Michael S. Seaman。

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