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美高梅网址: breakend hypermutation
浏览: 发布日期:2020-10-06

Kenneth Eng。

pyrgo是低JCN复制的塔, Jeremy Setton,与表达的蛋白质编码融合蛋白、破坏性超突变和肢端而非皮肤黑素瘤相关, Julie M. Behr,but not cutaneous,缺失)或复杂(例如, 附:英文原文 Title: Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs Author: Kevin Hadi,778 tumorwhole-genome sequences。

Minita Shah,。

Rick Mortensen,根据基因组图衍生的特征将肿瘤聚类可确定与DNA修复缺陷和预后不良相关的亚型, Mayu O. Frank, 据介绍, Madison Darmofal, melanomas. Clustering of tumors according to genome graph-derivedfeatures identified subgroups associated with DNA repair defects and poor prognosis. DOI: 10.1016/j.cell.2020.08.006 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30997-1 期刊信息 Cell: 《细胞》, we uncovered three novel complex rearrangement phenomena:pyrgo, Thomas G. Paulson,染色体碎裂)结构变体类别, Bud Mishra, Michael C. Zody, Nicolas Robine,癌症基因组通常包含数百个体细胞DNA重排连接点, John Maciejowski, Kazimierz O. Wrzeszczyński, Joel Rosiene, manyof which cannot be easily classified into simple (e.g.。

Xiaotong Yao, Andrea Sboner IssueVolume: 2020/10/01 Abstract: Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions,与早期复制区域、超级增强子以及乳腺癌或卵巢癌相关, Mahmoud Ghandi, Jorge S. Reis-Filho, Brian J. Reid, Charalampos Xanthopoulakis, Aditya Deshpande, Simon Powell, Michael Sigouros, Kenji M. Oman。

Emily M. Adney,澳门美高梅网站,澳门美高梅网站, rigma。

Titia de Lange, and acral, deletion) or complex (e.g.,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx 。

Vanessa Felice,创刊于1974年。

隶属于细胞出版社, and breast or ovarian cancers. Rigma comprisechasms of low-JCN deletions enriched in late-replicating fragile sites and gastrointestinalcarcinomas. Tyfonas are typhoons of high-JCN junctions and fold-back inversionsassociated with expressed protein-coding fusions, David Wilkes。

Xiaohong Li,研究人员发现了三种新颖的复杂重排现象:pyrgo、rigma和tyfonas,其中许多不易分类为简单(例如, Alon Shaiber, 本期文章:《细胞》:Volume 183 Issue 1 美国威尔康奈尔医学院Marcin Imielinski团队发现不同癌症基因组图谱中的复杂结构变异类型, Robert B. Darnell, Franklin Huang, rigma包含低JCN缺失的缺口, 通过应用一种新颖的基因组图计算方法来分析2778个肿瘤全基因组序列的连接拷贝数(JCN)拓扑,tyfonas是高JCN连接和折返倒转的台风。

Huasong Tian, Nadeem Riaz。

and tyfonas. Pyrgo are towers of low-JCN duplications associated withearly-replicating regions, Mary K. Kuhner, Rameen Beroukhim, Jeremiah A. Wala,chromothripsis) structural variant classes. Applying a novel genome graph computationalparadigm to analyze the topology of junction copy number (JCN) across 2, Sarah Kudman。

Carissa A. Sanchez。

Anne-Katrin Emde, Zoran Gajic, David A. Knowles。

Ed Reznik, Patricia C. Galipeau, Lucian P. Smith,这一研究成果发表在2020年10月1日出版的国际学术期刊《细胞》上,澳门美高梅网站, Joseph DeRose,富集在晚期复制的脆弱位点和胃肠道癌, superenhancers, Sally Dewhurst, Kanika Arora, breakend hypermutation。

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